ENSDARG00000098344


Danio rerio

Features
Gene ID: ENSDARG00000098344
  
Biological name :rab18b
  
Synonyms : Q6DHC1 / rab18b / RAB18B, member RAS oncogene family
  
Possible biological names infered from orthology : P35293 / Q9NP72 / RAB18 / RAB18, member RAS oncogene family
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 4019538
Gene end: 4032732
  
Corresponding Affymetrix probe sets: Dr.10411.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000133937
NCBI entrez gene - 445055     See in Manteia.
RefSeq - NM_001003449
RefSeq Peptide - NP_001003449
swissprot - Q6DHC1
ZFIN ID - ZDB-GENE-040801-185
Ensembl - ENSDARG00000098344
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RAB18ENSGALG00000007435Gallus gallus
 RAB18ENSG00000099246Homo sapiens
 Rab18ENSMUSG00000073639Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rab18a / RAB18A, member RAS oncogene family / RAB18* / Q9NP72* / P35293* / RAB18, member RAS oncogene family*ENSDARG0000005529184
rab2a / RAB2A, member RAS oncogene family / P53994* / P61019* / Ras-related protein Rab-2A *ENSDARG0000002026143
rab11al / RAB11a, member RAS oncogene family, likeENSDARG0000001434041
rab11bb / RAB11B, member RAS oncogene family, b / RAB11B* / P46638* / Q15907* / RAB11B, member RAS oncogene family*ENSDARG0000009008640
rab11a / RAB11a, member RAS oncogene familyENSDARG0000004145040
rab11ba / RAB11B, member RAS oncogene family, a / RAB11B* / P46638* / Q15907* / RAB11B, member RAS oncogene family*ENSDARG0000004187840
rab25b / RAB25, member RAS oncogene family b / RAB25* / P57735* / RAB25, member RAS oncogene family*ENSDARG0000005295440
rab25a / RAB25, member RAS oncogene family a / RAB25* / Q9WTL2* / P57735* / RAB25, member RAS oncogene family*ENSDARG0000005880039
rab14l / RAB14, member RAS oncogene family, likeENSDARG0000003518839
rab14 / RAB14, member RAS oncogene family / P61106* / Q91V41*ENSDARG0000007424639
rab4b / RAB4B, member RAS oncogene family / Q91ZR1* / P61018* / RAB4B-EGLN2* / RAB4B-EGLN2 readthrough (NMD candidate)*ENSDARG0000001217738
rab4a / Q6PHI9 / RAB4a, member RAS oncogene family / P56371* / P20338* / Ras-related protein Rab-4A *ENSDARG0000001914438
rab42a / RAB42, member RAS oncogene family aENSDARG0000003421537
rab42b / RAB42, member RAS oncogene familyENSDARG0000010117036
CU571310.1 / RAB42* / Q8N4Z0* / RAB42, member RAS oncogene family*ENSDARG0000010258035
rab39bb / RAB39B, member RAS oncogene family b / RAB39B* / Q8BHC1* / Q96DA2* / RAB39B, member RAS oncogene family*ENSDARG0000003650134
rab39ba / RAB39B, member RAS oncogene family a / RAB39B* / Q8BHC1* / Q96DA2* / RAB39B, member RAS oncogene family*ENSDARG0000001931234
si:dkey-34d22.2ENSDARG0000010037930
si:dkey-34d22.5ENSDARG0000010486528
si:ch211-247i17.1ENSDARG0000007672721


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR025662  Sigma-54 interaction domain, ATP-binding site 1
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001654 eye development IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0034389 lipid particle organization IBA
 biological_processGO:0043009 chordate embryonic development IMP
 cellular_componentGO:0005794 Golgi apparatus IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
COPI-independent Golgi-to-ER retrograde traffic
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000035 lens lens non-functional , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
eye deformed , abnormal
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 ZFA:0001094 whole organism whole organism decreased size , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton malformed , abnormal
mandibular arch skeleton immature , abnormal
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 ZFA:0001284 optic fissure optic fissure closure incomplete , abnormal
optic fissure open , abnormal
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 ZFA:0009199 iridophore iridophore low saturation , abnormal
iridophore absent , abnormal
iridophore decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000044136 rab3gap2 / RAB3 GTPase activating protein subunit 2 (non-catalytic) / Q9H2M9* / RAB3 GTPase activating non-catalytic protein subunit 2*  / reaction / complex
 ENSDARG00000056122 gdi1 / GDP dissociation inhibitor 1 / P31150* / P50396* / Rab GDP dissociation inhibitor alpha *  / complex






 

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